Timothy syndrome 1 genotype without syndactyly and major extracardiac manifestations

A rare association with suffered cardiac arrest, long QT interval, and syndactyly: Timothy syndrome (LQT-8)

Extracardiac manifestations of bacterial endocarditis.

Bacterial endocarditis is an elusive disease that challenges clinicians' diagnostic capabilities. Because it can present with various combinations of extravalvular signs and symptoms, the underlying primary disease can go unnoticed.A review of the various extracardiac manifestations of bacterial endocarditis suggests three main patterns by which the valvular infection can be obscured. (1) A maj...

Sudden Cardiac Arrest during Anesthesia in a 30-Month-Old Boy with Syndactyly: A Case of Genetically Proven Timothy Syndrome

Timothy syndrome, long QT syndrome type 8, is highly malignant with ventricular tachyarrhythmia. A 30-month-old boy had sudden cardiac arrest during anesthesia induction before plastic surgery for bilateral cutaneous syndactyly. After successful resuscitation, prolonged QT interval (QTc, 0.58-0.60 sec) and T-wave alternans were found in his electrocardiogram. Starting β-blocker to prevent furth...

I-12 Timothy Syndrome and Cardiomyopathy

potentials and twitch force were measured in muscle strips obtained from patients and controls. Of the 36 patients, 25 presented with chronic muscle weakness of varying degrees, up to wheelchair-dependence. The weakness was associated with intracellular Na overload and edema. Older patients revealed a vacuolar myopathy or a progressive muscular dystrophy. Weakness, intracellular Na overload and...

Onm-1: Self-Confidence in Women with and without Polycystic Ovary Syndrome

Background: Polycystic Ovary Syndrome (PCOS) as other chronic diseases causes dependence and decreasing body control. It also causes unworthy unsafely, negative suggestions and decreasing of Self-confidence. The aim of this comparative study was comparing Selfconfidence in woman with and without PCOS according to their ages. Materials and Methods: This comparative study conducted between 100 wo...